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However, other mechanisms proposed include the modification of protein thiols, destruction of iron–sulfur centers contained in CI and CII, or opening of the permeability transition pore, which results in the loss of cytochrome c and contributes to respiratory inhibition (Poderoso et al., 2019

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SS-31 vs MOTS-c: Mitochondrial Peptides SS-31 stabilizes cardiolipin, MOTS-c activates AMPK — different targets, different results